Bolus Fibrinolysis

Bolus fibrinolysis: risk, benefit, and opportunities.

Fibrinolytic therapy for acute ST-segment elevation myocardial infarction has made a major contribution to the care of thousands of patients worldwide.1 Over the past decade, there have been tremendous advances in the care of such patients, including an enhanced assessment of both the risks of the infarction and the potential for complicating intracranial hemorrhage (ICH), more effective reperf...

Comparative Fibrinolysis

Pharmacological Fibrinolysis

Until fairly recently, arteriosclerosis and its complications were philosophically accepted as an inevitable consequence of ageing; but the steady increase of coronary deaths in particular, and the equally steady decrease ^ the age of onset have put an end to such laissez-faire complacency. To Pinpoint the epidemic acceleration of coronary deaths, a senior colleague told me that when he took th...

Oesophageal pressure-flow metrics in relation to bolus volume, bolus consistency, and bolus perception.

BACKGROUND The utility of combined oesophageal pressure-impedance recording has been enhanced by automation of data analysis. OBJECTIVE To understand how oesophageal function as measured by automated impedance manometry (AIM) pressure-flow analysis varies with bolus characteristics and subjective perception of bolus passage. METHODS Oesophageal pressure-impedance recordings of 5 and 10 ml l...

To bolus or not to bolus--is that the question?